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J Korean Wound Management Soc > Volume 10(1); 2014 > Article
Journal of the Korean Wound Management Society 2014;10(1): 14-19.
희석하지 않은 신속 응고형 고농도 Thrombin이 함유된Fibrin Glue를 이용한 부분층 피부이식편의 고정
가톨릭대학교 의과대학 성형외과학교실
Skin Graft Fixation Using Fast-clotting Fibrin Glue
Hyun Ho Han, In Sook Kang, Suk-Ho Moon
Department of Plastic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Kora
  Published online: 30 May 2014.
Sutures and staplers have been widely used for graft fixation, and since the 2000s, fibrin has also been used. To use fibrin, autologous blood is collected and processed, or commercial products are diluted to prepare low-concentration fibrin glues, requiring substantial time and effort. For graft fixation, a fast-clotting fibrin sealant containing 400 IU/ml thrombin was used for all subjects. At 5 days postoperatively, and the graft hematoma/seroma incidence and graft dislocation rates were investigated. At 30 days postoperatively, the graft necrosis and graft-take rates were investigated. The surface area was calculated using ImageJ (US National Institutes of Health, Bethesda, MD, USA). The size of the defect area ranged from 3 cm×2 cm to 22 cm×5 cm. At 5 days postoperatively, the mean hematoma/seroma incidence and graft dislocation rates were 7.84% and 1.29%, respectively. At 30 days postoperatively, the graft necrosis and graft-take rates were 0.76% and 99.24%, respectively. When high-concentration fast-clotting fibrin sealants were applied to skin grafts without a dilution process, no difficulty was experienced during the surgery, and the results were similar to those of slow-clotting fibrin sealants with excellent skin graft-take rates. (J Korean Wound Management Soc 2014;10:14-19)
Key Words: Fibrin sealant, Thrombin, Split thickness skin graft
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