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Journal of the Korean Wound Management Society 2010;6(2): 062-068. |
| 생물학적 창상피복재로서 돼지피부의 연구 |
| 최다미1ㆍ김진영1ㆍ안재형1ㆍ강계원1ㆍ김완희2ㆍ김 진3 |
| 1한스바이오메드 대덕연구소 조직공학연구본부, 2서울대학교 수의과대학 수의외과학, 3가톨릭대학교 대전성모병원 구강외과 |
| The Study of Porcine Skin as the Biological Wound Dressing |
| Da Mi Choi1, Jin Young Kim1, Jae Hyoung Ahn1, Ke Won Kang1, Wan Hee Kim2, Jin Kim3 |
| 1Hans Daedeok R&D Center, Hans Biomed Corp., Daejeon, 2Department of Veterinary Surgery, College of Veterinary Medicine, Seoul National University, Seoul, 3Department of Oral and Maxillofacial Surgery, Daejeon St. Mary |
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Published online: 30 November 2010. |
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| ABSTRACT |
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As the biological wound dressing materials, commercial human skin originated from cadaver is mainly used in general. However in the case of products derived from human skin, supply is limited through donations. To the resolve such problems, we examined possibility of wound dressing derived from porcine skin to replace human skin-derived wound dressing. Porcine skins were procured using Padgett Electric Dermatome (IntegraTM) and manufacturing process was followed as human cadaver skin (Hans Biomed Procedures). In this study, structural, physical and biological properties of human skin and porcine skin were compared by scanning electron microscope (SEM), histological analysis, immunohistochemistry (IHC), tensile strength and GAGs assay. And a beagle dog was used in vivo experiment, induced (5×5) cm wounds and applied dressing materials from porcine skin derived products and control. In histological result, porcine skin is anatomically similar to human skin and showed the presence of collagen I, IV, VII, elastin, desmin etc. Also in the animal experiment, porcine skin-derived wound dressing (GPPS) group had epithelization, neovasculature than control group. These results indicate that biological wound dressing such as porcine skin has application of possibility and advantages. (J Korean Wound Management Soc 2010;6:62-68) |
| Key Words:
Biological wound dressing, Porcine skin, Glycerol preserved skin, Wound healing, Xenograft |
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