Effect of Hyaluronic Acid Based Dressing on Wound Healing

J Korean Wound Management Soc > Volume 6(1); 2010 > Article

Original Article

Journal of the Korean Wound Management Society 2010;6(1): 001-009.

전층 창상에서 하이알룬산 제재의 치유효과

정호윤ㆍ송재민ㆍ이정훈ㆍ최강영ㆍ김귀락ㆍ양정덕ㆍ조병채

경북대학교 의과대학 성형외과학교실

Effect of Hyaluronic Acid Based Dressing on Wound Healing

Ho Yun Chung, Jae Min Song, Jung Hun Lee, Kang Young Choi, Gui Rak Kim, Jung Dug Yang, Byung Chae Cho

Department of Plastic and Reconstructive Surgery, College of Medicine, Kyungpook National University, Daegu, Korea

Published online: 31 May 2010.

ABSTRACT

Hyaluronic acid (HA) is a major carbohydrate component of the extracellular matrix. It creates a hydrophilic environment and plays an important role in the process of tissue repair. We used hyaluronic acid based dressing materials to evaluate the effects on wound healing and compared them with other dressing materials through the experiment using Sprague-Dawley rats. We divided the wound into four groups of dressing material: Group A with HA mesh (Connettivina^Ⱂpad) and HA gel (Connettivina^Ⱂ 0.2% gel), Group B with HA mesh only, Group C with Chlorhexidine acetate mesh (Bactigras^Ⱂ), Group D with gauze as a negative control group. We compared each group with gross findings by tracing the remained wound, histological test on each time periods. This study suggest hyaluronic acid based dressing induces stable reepithelization and collagen synthesis in the wound healing process, and is expected as one of effective dressing material for treatment of wound healing. (J Korean Wound Management Soc 2010;6:1-9)

Key Words: Hyaluronic acid, Wound healing, Dressing, Connettivina^Ⱂ;