Response to Letter: The Ongoing Challenges: Comments on “Clinical Outcomes of Negative-Pressure Wound Therapy with Instillation without Commercial Devices in the Treatment of Complex Wounds”

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J Wound Manag Res. 2023;19(3):238-239
Publication date (electronic) : 2023 October 30
doi :
1Pusan National University School of Medicine, Yangsan, Korea
2Department of Plastic and Reconstructive Surgery, Biomedical Research Institute & Pusan National University Hospital, Busan, Korea
3Department of Plastic and Reconstructive Surgery, Pusan National University School of Medicine, Yangsan, Korea
Corresponding author: Joo Hyoung Kim, MD, PhD Department of Plastic and Reconstructive Surgery, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea E-mail:
Received 2023 August 29; Revised 2023 August 30; Accepted 2023 August 30.

In Reply

We would like to thank the authors for the well-referenced comments on this paper [1]. Based on our experience of using non-commercial-device negative-pressure wound therapy with instillation (NPWTi), we are in the process of developing an automated, controlled, commercial NPWTi device together with a medical device manufacturer, and are currently conducting animal experiments using a prototype.

Following are the answers to your questions for case 2 [1,2]: as you know, it is difficult to guess the state of wounds based solely on the external appearance. Therefore, debridement was performed not only to clean the wound, but also to determine the extent of the infection. The middle one-third of the wound was affected to the deep fascia layer, consistent with the definition of deep surgical site infection. We used an intravenous extension line for our instillation system, which can be placed in deep, narrow wounds like this case. The wound was irrigated with NPWTi for 4 weeks, and the infection resolved after 11 days without additional surgical debridement. After the infection was controlled, a local advancement flap was done for reconstruction of the soft tissue defect after debridement. Secondary intention healing can be achieved through the prolonged use of NPWTi, but surgical reconstruction was conducted to overcome the disadvantage of our NPWTi—it requires hospitalization of the patient. We used a 1% povidone-iodine solution routinely for irrigation in our NPWTi, with no allergic reaction in any of the cases. But, all antiseptics can cause side effects including allergic reactions, so careful observation is required when using such solutions for instillation.

We strongly agree with your view that it is difficult to organize well-designed clinical trials investigating the effectiveness of NPWTi due to wound inhomogeneity and pathogen diversity. We are grateful for the opportunity to discuss more about this subject. We hope to continue discussions on the reliability of NPWTi in the near future.


This work was supported by the Korea Medical Device Development Fund grant funded by the Korea government (the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health & Welfare, the Ministry of Food and Drug Safety) (Project Number: 1711192933, RS-2022-00164579) and clinical research grant from Pusan National University Hospital in 2023. No other potential conflict of interest relevant to this article was reported.


1. Popivanov G, Kjossev K, Mutafchiyski V. The ongoing challenges: comments on “Clinical outcomes of negative-pressure wound therapy with instillation without commercial devices in the treatment of complex wounds”. J Wound Manag Res 2023;19:244–5.
2. Sung JY, Bae YC, Nam SB, et al. Clinical outcomes of negative-pressure wound therapy with instillation without commercial devices in the treatment of complex wounds. J Wound Manag Res 2020;16:13–20.

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