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Journal of the Korean Wound Management Society 2016;12(2): 39-45. |
| 지방줄기세포치료의 현재와 미래 |
| 이종원ᆞ김기주 |
| 가톨릭대학교 서울성모병원 성형외과 |
| Adipose Stem Cell Therapy: Present, Future |
| Jong-Won Rhie, Ki Joo Kim |
| Department of Plastic Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea |
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Published online: 30 November 2016. |
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| ABSTRACT |
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Adipose tissue is an ideal tissue as an autologous substitute with which to approach tissue deficiency. Clinically, use of fat grafts and adipose derived stem cells (ASCs) has dramatically increased worldwide for reconstructive and regenerative medicine. Human adipose tissue contains a population of pluripotent stem cells capable of differentiating along multiple mesenchymal cell lineages. Adipose tissue is an abundant, expendable, and easily obtained tissue that may prove to be an ideal source of autologous mesenchymal stem cells (MSCs) for regenerating tissues. The recent identification and characterization of multilineage cells from human adipose tissue has been met with a great deal of excitement by the field of tissue engineering. In recent years, literature based on data related to Stromal Vascular Fraction (SVF) cells and ASCs has augmented considerably: These studies have demonstrated the efficacy and safety of SVF cells and ASCs in vivo in animal models. On the basis of these observations, in several countries, various clinical trials involving SVF cells and ASCs have been permitted.In this review, I highlight basic study of the adipose tissue for multipotential stem cell source of tissue engineering techniques and summarize data regarding either ASCs cellular biology or ASCs-based clinical trials and discuss the possible future clinical translation of mesenchymal stem cell (MSC) and their potentiality in cell-based tissue engineering. (J Korean Wound Management Soc 2016;12:39-45) |
| Key Words:
Mesenchymal stem cell, Adipose stem cell, Cell theraphy |
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