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J Korean Wound Management Soc > Volume 6(1); 2010 > Article
Journal of the Korean Wound Management Society 2010;6(1): 010-014.
누드마우스의 전층결손 창상모델에서 하이드로겔 창상피복제의 효과
1(주)엠씨티티 부설연구소, 2성균관대학교 의과대학 삼성서울병원 성형외과학교실
Effect of Hydrogel Dressing for Wound Healing in Full-thickness Wound on Nude Mouse
Sae-Hwan Lim1, Hyeong Uk Yu1, So Jeong Yoon1, Chang Woong Park1, Kap Sung Oh2
1Research and Development Institute, MCTT Co., Ltd, Technopark, 2Department of Plastic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  Published online: 31 May 2010.
PlusubgelTM (MCTT Co. Ltd) is a new amorphous hydrogel wound dressing that are specially formulated to help provide a moist environment to enhance wound healing. Hydrogel wound dressing help to maintain a moist wound environment recognized as being beneficial in wound healing. They are non-adherent and can be removed without trauma to the wound. In addition, hydrogel wound dressings are effective, comfortable, easy to use and cost effective. This study was designed to evaluate the wound healing effects of PlusubgelTM in the treatment of full-thickness wounds (8 mmØ) in mice. A total of 60 mice were used in this study. 30 mice were treated with PlusubgelTM, followed by second dressing (i.e. Mepitel & Tegaderm), and 30 mice with a second dressing alone. Biopsy samples were taken at 4, 7 and 14 days post operation, and each wound site was examined histopathologically. Histopathologic evaluation included monitoring of epithelialization and granulation tissue formation. The results were as follow; Acceleration of epithelization across the wound surface was noted following PlusubgelTM treatment. Increase in the thickness of granulation tissue was observed in the PlusubgelTM-treated groups as compared with the control groups. It can be concluded that PlusubgelTM might be a potential treatment material for wound healing. (J Korean Wound Management Soc 2010;6:10-14)
Key Words: Hydrogel dressing, Wound healing, Epithelialization
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